1. Biological Components:
Covishield is a viral vector vaccine. It uses a weakened, non-replicating strain of Chimpanzee
cold virus (adenovirus) to carry genetic material of the spike protein of SARS-CoV-2 into human cells.
Covaxin contains an inactivated SARS-CoV-2 (Strain: NIV-2020-770) which is disabled for
replication. However, the proteins are intact which are able to provoke immunity of the host.
There are other chemical ingredients in the form of excipients which are detailed out below.
2. Chemical Ingredients:
Covishield
- L-Histidine Ethanol
- L-Histidine Hydrochloride Monohydrate
- Magnesium Chloride Hexahydrate
- Polysorbate 80*
- Sucrose
- Sodium Chloride
- Disodium Edetate Dihydrate (EDTA)
- Water for injection
Covaxin
- Aluminum Hydroxide gel
- Imidazoquinolinone # (TLR 7/8 agonist)
- 2-Phenoxyethanol
- Phosphate buffer saline
*Polysorbate 80 which is an ingredient of Covishield is known to cause anaphylactic reactions in patients whereas Covaxin has no such component.
#Also known as Algel-IMDG which is an adjuvant required for Covaxin but not for Covishield.
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